As the number of COVID-19 cases continues to reach new highs, social distancing and face masks are more essential than ever to keep you safe. However, doing patch clamp experiments using traditional methods is nearly impossible while wearing a face mask.  NeoBiosystems' ez-gSEAL 100B Pressure Controller is an instrument that allows you to conduct patch clamp experiments through button clicking. It has been used in many labs to successfully perform the patch clamp technique for electrophysiology recording on a variety of cell types [1, 2, 3]. It has additionally been used for collecting single cell aRNA for sequencing [4], and its precise nature has allowed it to be used for studying the mechanical properties of a cell [5].

We will apply a COVID-19 discount to any purchase made by the end of the year.  Please send an email to sales@neobiosystems.com for details. Do not reply to this email.

References:

1. Alan Kania, Agata Szlaga, Patryk Sambak, Anna Gugula, Ewa Blasiak, Maria Vittoria Micioni Di Bonaventura, Mohammad Akhter Hossain, Carlo Cifani, Grzegorz Hess, Andrew L. Gundlach and Anna Blasiak (2020) RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior. https://www.jneurosci.org/content/40/28/5362.abstract

2. Arik J. Hone, Erin L. Meyer, Melissa McIntyre, J. Michael McIntosh (2011) Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the a6ß4 subtype. https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.11-195883

3. JinBin Tian, Chhavy Tep, Alex Benedick, Nabila Saidi, Jae Cheon Ryu, Mi Lyang Kim, Shankar Sadasivan, John Oberdick, Richard Smeyne, Michael X. Zhu, and Sung Ok Yoon (2014) p75 regulates Purkinje cell firing by modulating SK channel activity through Rac1. https://www.jbc.org/content/289/45/31458.short

4. Hae Gyun Lim, Hsiao-Chuan Liu, Chi Woo Yoon, Hayong Jung, Min Gon Kim, Changhan Yoon, Hyung Ham Kim & K. Kirk Shung (2020) Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study. https://www.nature.com/articles/s41378-020-0150-6

5. Jae Mun "Hugo" Kim, Adrian Camarena, Christopher Walker, Ming Yi Lin, Victoria Wolseley, Tade Souaiaia, Matthew Thornton, Brendan Grubbs, Robert H. Chow, Oleg V. Evgrafov & James A. Knowles (2020) Robust RNA-Seq of aRNA-amplified single cell material collected by patch clamp. https://www.nature.com/articles/s41598-020-58715-y

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